Neuronal Death After Hemorrhagic Stroke In Vitro and In Vivo Shares Features of Ferroptosis and Necroptosis | Zendy

Marietta Zille | Zendy; Saravanan S. Karuppagounder | Zendy; Yingxin Chen | Zendy; Peter J. Gough | Zendy; John Bertin | Zendy; Joshua N. Finger | Zendy; Teresa A. Milner | Zendy; Elizabeth A. Jonas | Zendy; Rajiv R. Ratan | Zendy

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Neuronal Death After Hemorrhagic Stroke In Vitro and In Vivo Shares Features of Ferroptosis and Necroptosis

Author(s) -

Marietta Zille,

Saravanan S. Karuppagounder,

Yingxin Chen,

Peter J. Gough,

John Bertin,

Joshua N. Finger,

Teresa A. Milner,

Elizabeth A. Jonas,

Rajiv R. Ratan

Publication year - 2017

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.116.015609

Subject(s) - necroptosis , programmed cell death , hemin , apoptosis , microbiology and biotechnology , medicine , autophagy , intracerebral hemorrhage , necrosis , in vivo , cancer research , pathology , biology , biochemistry , heme , enzyme , subarachnoid hemorrhage

Intracerebral hemorrhage leads to disability or death with few established treatments. Adverse outcomes after intracerebral hemorrhage result from irreversible damage to neurons resulting from primary and secondary injury. Secondary injury has been attributed to hemoglobin and its oxidized product hemin from lysed red blood cells. The aim of this study was to identify the underlying cell death mechanisms attributable to secondary injury by hemoglobin and hemin to broaden treatment options.

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