ABCA1/ApoE/HDL Pathway Mediates GW3965-Induced Neurorestoration After Stroke | Zendy

Xu Cui | Zendy; Michael Chopp | Zendy; Zhenggang Zhang | Zendy; Rongwen Li | Zendy; Alex Zacharek | Zendy; Julie LandschootWard | Zendy; Poornima Venkat | Zendy; Jieli Chen | Zendy

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ABCA1/ApoE/HDL Pathway Mediates GW3965-Induced Neurorestoration After Stroke

Author(s) -

Xu Cui,

Michael Chopp,

Zhenggang Zhang,

Rongwen Li,

Alex Zacharek,

Julie LandschootWard,

Poornima Venkat,

Jieli Chen

Publication year - 2016

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.116.015592

Subject(s) - abca1 , medicine , endocrinology , apolipoprotein e , liver x receptor , cholesterol , transporter , biology , biochemistry , disease , nuclear receptor , transcription factor , gene

ATP-binding cassette transporter A1 (ABCA1) is a major reverse cholesterol transporter and plays critical role in the formation of brain high-density lipoprotein (HDL) cholesterol. Apolipoprotein E (ApoE) is the most abundant apolipoprotein and transports cholesterol into cells in brain. ABCA1 and ApoE are upregulated by liver-X receptors. Activation of liver-X receptors has neurorestorative benefit for stroke. The current study investigates whether ABCA1/ApoE/HDL pathway mediates GW3965, a synthetic dual liver-X receptor agonist, induced neurorestoration after stroke.

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