Monocyte Chemotactic Protein-1–Interleukin-6–Osteopontin Pathway of Intra-Aneurysmal Tissue Healing | Zendy

Koji Hosaka | Zendy; Kelley Rojas | Zendy; Hanain Fazal | Zendy; Matheus B. Schneider | Zendy; Jorma Shores | Zendy; Vincent P. Federico | Zendy; Matthew McCord | Zendy; Lin Li | Zendy; Brian L. Hoh | Zendy

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Monocyte Chemotactic Protein-1–Interleukin-6–Osteopontin Pathway of Intra-Aneurysmal Tissue Healing

Author(s) -

Koji Hosaka,

Kelley Rojas,

Hanain Fazal,

Matheus B. Schneider,

Jorma Shores,

Vincent P. Federico,

Matthew McCord,

Lin Li,

Brian L. Hoh

Publication year - 2017

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.116.015590

Subject(s) - medicine , osteopontin , monocyte , chemotaxis , interleukin , pathology , immunology , cytokine , receptor

We have previously demonstrated that the local delivery of monocyte chemotactic protein-1 (MCP-1) via an MCP-1-releasing poly(lactic-co-glycolic acid)-coated coil promotes intra-aneurysmal tissue healing. In this study, we demonstrate that interleukin-6 (IL-6) and osteopontin are downstream mediators in the MCP-1-mediated aneurysm-healing pathway.

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