Targeting Different Monocyte/Macrophage Subsets Has No Impact on Outcome in Experimental Stroke | Zendy

Antje Schmidt | Zendy; JanKolja Strecker | Zendy; Stephanie Hucke | Zendy; Nils Martin Bruckmann | Zendy; Martin Herold | Zendy; Matthias Mack | Zendy; Kai Diederich | Zendy; WolfRüdiger Schäbitz | Zendy; Heinz Wiendl | Zendy; Luisa Klotz | Zendy; Jens Minnerup | Zendy

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Targeting Different Monocyte/Macrophage Subsets Has No Impact on Outcome in Experimental Stroke

Author(s) -

Antje Schmidt,

JanKolja Strecker,

Stephanie Hucke,

Nils Martin Bruckmann,

Martin Herold,

Matthias Mack,

Kai Diederich,

WolfRüdiger Schäbitz,

Heinz Wiendl,

Luisa Klotz,

Jens Minnerup

Publication year - 2017

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.116.015577

Subject(s) - medicine , proinflammatory cytokine , monocyte , stroke (engine) , macrophage , inflammation , immunology , pathology , in vitro , biology , biochemistry , mechanical engineering , engineering

Peripheral immune cell infiltration contributes to neural injury after ischemic stroke. However, in contrast to lymphocytes and neutrophils, the role of different monocyte/macrophage subsets remains to be clarified. Therefore, we evaluated the effects of selective and unselective monocyte/macrophage depletion and proinflammatory (M1-) and anti-inflammatory (M2-) macrophage transfer on the outcome after experimental cerebral ischemia.

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