Selective Sphingosine 1-Phosphate Receptor 1 Agonist Is Protective Against Ischemia/Reperfusion in Mice | Zendy

Vanessa H. Brait | Zendy; Gema Tarrasón | Zendy; Amadeu Gavaldà | Zendy; Núria Godessart | Zendy; Anna M. Planas | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Selective Sphingosine 1-Phosphate Receptor 1 Agonist Is Protective Against Ischemia/Reperfusion in Mice

Author(s) -

Vanessa H. Brait,

Gema Tarrasón,

Amadeu Gavaldà,

Núria Godessart,

Anna M. Planas

Publication year - 2016

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.116.015371

Subject(s) - fingolimod , medicine , agonist , pharmacology , ischemia , receptor , sphingosine 1 phosphate receptor , stroke (engine) , anesthesia , sphingosine , sphingosine 1 phosphate , immunology , multiple sclerosis , mechanical engineering , engineering

Growing evidence supports that the immunomodulatory drug fingolimod is protective in stroke. Fingolimod binds to 4 of 5 sphingosine-1-phosphate (S1P) receptors and, among other actions, it induces lymphopenia. In this study, we investigated whether a selective S1P1 agonist is protective in experimental stroke.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research