Cyclooxygenase-2-Derived Prostaglandins Mediate Cerebral Microcirculation in a Juvenile Ischemic Rat Model | Zendy

PierreLouis Léger | Zendy; Julien Pansiot | Zendy; Valérie C. Besson | Zendy; Bruno Palmier | Zendy; Sylvain Renolleau | Zendy; Olivier Baud | Zendy; Bruno Cauli | Zendy; Christiane CharriautMarlangue | Zendy

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Cyclooxygenase-2-Derived Prostaglandins Mediate Cerebral Microcirculation in a Juvenile Ischemic Rat Model

Author(s) -

PierreLouis Léger,

Julien Pansiot,

Valérie C. Besson,

Bruno Palmier,

Sylvain Renolleau,

Olivier Baud,

Bruno Cauli,

Christiane CharriautMarlangue

Publication year - 2016

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.116.015095

Subject(s) - tunel assay , cyclooxygenase , prostacyclin , medicine , prostaglandin , ischemia , nitric oxide synthase , endocrinology , microcirculation , terminal deoxynucleotidyl transferase , prostaglandin e , immunostaining , cerebral blood flow , pharmacology , nitric oxide , enzyme , biology , biochemistry , immunohistochemistry

We previously showed that the selective neuronal nitric oxide synthase inhibitor 7-nitroindazole (7-NI) increases cerebral microcirculation in a juvenile ischemic rat model. We address the roles of cyclooxygenase (COX)-elaborated prostaglandins in collateral recruitment and blood supply.

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