Valproate Reduces Delayed Brain Injury in a Rat Model of Subarachnoid Hemorrhage | Zendy

Arend M. Hamming | Zendy; Annette van der Toorn | Zendy; Umesh Rudrapatna | Zendy; Lisha Ma | Zendy; Hine J.A. van Os | Zendy; Michel D. Ferrari | Zendy; Arn M. J. M. van den Maagdenberg | Zendy; Erik W. van Zwet | Zendy; Katherine Poinsatte | Zendy; Ann Stowe | Zendy; Rick M. Dijkhuizen | Zendy; Marieke J.H. Wermer | Zendy

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Valproate Reduces Delayed Brain Injury in a Rat Model of Subarachnoid Hemorrhage

Author(s) -

Arend M. Hamming,

Annette van der Toorn,

Umesh Rudrapatna,

Lisha Ma,

Hine J.A. van Os,

Michel D. Ferrari,

Arn M. J. M. van den Maagdenberg,

Erik W. van Zwet,

Katherine Poinsatte,

Ann Stowe,

Rick M. Dijkhuizen,

Marieke J.H. Wermer

Publication year - 2016

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.116.014738

Subject(s) - medicine , lesion , subarachnoid hemorrhage , magnetic resonance imaging , anesthesia , ischemia , valproic acid , analysis of variance , pathology , radiology , epilepsy , psychiatry

Spreading depolarizations (SDs) may contribute to delayed cerebral ischemia after subarachnoid hemorrhage (SAH). We tested whether SD-inhibitor valproate reduces brain injury in an SAH rat model with and without experimental SD induction.

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