Selecting Patients for Intra-Arterial Therapy in the Context of a Clinical Trial for Neuroprotection | Zendy

Patrick D. Lyden | Zendy; Sara Weymer | Zendy; Christopher S. Coffey | Zendy; Merit Cudkowicz | Zendy; Samantha Berg | Zendy; Sarah Friedlander O'Brien | Zendy; Marc Fisher | Zendy; E. Clarke Haley | Zendy; Pooja Khatri | Zendy; Jeffrey L. Saver | Zendy; Steven R. Levine | Zendy; Howard Levy | Zendy; Marilyn M. Rymer | Zendy; Lawrence R. Wechsler | Zendy; Ashutosh P. Jadhav | Zendy; Elizabeth McNeil | Zendy; Salina P. Waddy | Zendy; Kent E. Pryor | Zendy

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Selecting Patients for Intra-Arterial Therapy in the Context of a Clinical Trial for Neuroprotection

Author(s) -

Patrick D. Lyden,

Sara Weymer,

Christopher S. Coffey,

Merit Cudkowicz,

Samantha Berg,

Sarah Friedlander O'Brien,

Marc Fisher,

E. Clarke Haley,

Pooja Khatri,

Jeffrey L. Saver,

Steven R. Levine,

Howard Levy,

Marilyn M. Rymer,

Lawrence R. Wechsler,

Ashutosh P. Jadhav,

Elizabeth McNeil,

Salina P. Waddy,

Kent E. Pryor

Publication year - 2016

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.116.013881

Subject(s) - medicine , clinical trial , stroke (engine) , context (archaeology) , odds ratio , adverse effect , confidence interval , intensive care medicine , physical therapy , mechanical engineering , paleontology , engineering , biology

The advent of intra-arterial neurothrombectomy (IAT) for acute ischemic stroke opens a potentially transformative opportunity to improve neuroprotection studies. Combining a putative neuroprotectant with recanalization could produce more powerful trials but could introduce heterogeneity and adverse event possibilities. We sought to demonstrate feasibility of IAT in neuroprotectant trials by defining IAT selection criteria for an ongoing neuroprotectant clinical trial.

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