Letter by Iannuccelli et al Regarding Article, “Paracetamol, Ibuprofen, and Recurrent Major Cardiovascular and Major Bleeding Events in 19 120 Patients With Recent Ischemic Stroke” | Zendy

Cristina Iannuccelli | Zendy; Manuela Di Franco | Zendy; Fabio M. Pulcinelli | Zendy

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Letter by Iannuccelli et al Regarding Article, “Paracetamol, Ibuprofen, and Recurrent Major Cardiovascular and Major Bleeding Events in 19 120 Patients With Recent Ischemic Stroke”

Author(s) -

Cristina Iannuccelli,

Manuela Di Franco,

Fabio M. Pulcinelli

Publication year - 2016

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.116.013868

Subject(s) - medicine , stroke (engine) , ischemic stroke , ibuprofen , cohort , prostaglandin endoperoxide synthase , cardiology , emergency medicine , ischemia , mechanical engineering , biochemistry , chemistry , enzyme inhibitor , engineering , in vitro , pharmacology

We read with a great interest the recent article published in Stroke by Gonzalez-Valcarcel et al1 on the association between paracetamol and ibuprofen use with major cardiovascular events or major bleeding in patients. The authors accomplished a huge task analyzing a cohort of 19 120 patients with recent ischemic stroke or transient ischemic attack of mainly atherothrombotic origin. They observed that patients who used paracetamol daily have a higher risk of major cardiovascular events; patients who used ibuprofen seems not to have a significant increase in the risk of major cardiovascular events, but the results become consistent when …

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