Circulating MicroRNAs as Novel Biomarkers of Stenosis Progression in Asymptomatic Carotid Stenosis | Zendy

Sandra Dolz | Zendy; David Górriz | Zendy; José Ignacio Tembl | Zendy; Dolors Sánchez | Zendy; Gerardo Fortea | Zendy; Vera Parkhutik | Zendy; Aída Lago | Zendy

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Circulating MicroRNAs as Novel Biomarkers of Stenosis Progression in Asymptomatic Carotid Stenosis

Author(s) -

Sandra Dolz,

David Górriz,

José Ignacio Tembl,

Dolors Sánchez,

Gerardo Fortea,

Vera Parkhutik,

Aída Lago

Publication year - 2016

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.116.013650

Subject(s) - medicine , asymptomatic , microrna , stenosis , stroke (engine) , microvesicles , subclinical infection , cardiology , oncology , bioinformatics , pathology , gene , mechanical engineering , biochemistry , chemistry , biology , engineering

Progression of asymptomatic carotid artery stenosis (ACAS) in patients with >50% luminal narrowing is considered a potential risk factor for ischemic stroke; however, subclinical molecular biomarkers of ACAS progression are lacking. Recent studies suggest a regulatory function for several microRNAs (miRNAs) on the evolution of carotid plaque, but its role in ACAS progression is mostly unknown. The aim of our study was to investigate a wide miRNA panel in peripheral blood exosomes from patients with ACAS to associate circulating miRNA expression profiles with stenosis progression.

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