Permeable Thrombi Are Associated With Higher Intravenous Recombinant Tissue-Type Plasminogen Activator Treatment Success in Patients With Acute Ischemic Stroke | Zendy

Emilie Santos | Zendy; Jan Willem Dankbaar | Zendy; Kilian M. Treurniet | Zendy; Alexander D. Horsch | Zendy; Yvo B.W.E.M. Roos | Zendy; L. Jaap Kappelle | Zendy; Wiro J. Niessen | Zendy; Charles B.L.M. Majoie | Zendy; Birgitta K. Velthuis | Zendy; Henk A. Marquering | Zendy; Luciën E. M. Duijm | Zendy; Koos Keizer | Zendy; Aad van der Lugt | Zendy; Diederik W.J. Dippel | Zendy; K. E. Droogh - de Greeve | Zendy; Henri P. Bienfait | Zendy; Marianne AA van Walderveen | Zendy; M.J.H. Wermer | Zendy; Geert J. Lycklama à Nijeholt | Zendy; Jelis Boiten | Zendy; D. Duyndam | Zendy; I.V. Kwa | Zendy; Joost Meijer | Zendy; E.J. van Dijk | Zendy; F.O. Kesselring | Zendy; Frederick J. A. Meijer | Zendy; Jan Albert Vos | Zendy; Wouter J. Schonewille | Zendy; W.J. van Rooij | Zendy; Paul L.M. de Kort | Zendy; C.C. Pleiter | Zendy; S. L. M. Bakker | Zendy; Joost Bot | Zendy; Marieke C. Visser | Zendy; Irene C. van der Schaaf | Zendy; Willem P.Th.M. Mali | Zendy; Tom van Seeters | Zendy; J.M. Niesten | Zendy; Geert Jan Biessels | Zendy; Merel J.A. Luitse | Zendy; Y. van der Graaf | Zendy

Open Access

Permeable Thrombi Are Associated With Higher Intravenous Recombinant Tissue-Type Plasminogen Activator Treatment Success in Patients With Acute Ischemic Stroke

Author(s) -

Emilie Santos,

Jan Willem Dankbaar,

Kilian M. Treurniet,

Alexander D. Horsch,

Yvo B.W.E.M. Roos,

L. Jaap Kappelle,

Wiro J. Niessen,

Charles B.L.M. Majoie,

Birgitta K. Velthuis,

Henk A. Marquering,

Luciën E. M. Duijm,

Koos Keizer,

Aad van der Lugt,

Diederik W.J. Dippel,

K. E. Droogh - de Greeve,

Henri P. Bienfait,

Marianne AA van Walderveen,

M.J.H. Wermer,

Geert J. Lycklama à Nijeholt,

Jelis Boiten,

D. Duyndam,

I.V. Kwa,

Joost Meijer,

E.J. van Dijk,

F.O. Kesselring,

Frederick J. A. Meijer,

Jan Albert Vos,

Wouter J. Schonewille,

W.J. van Rooij,

Paul L.M. de Kort,

C.C. Pleiter,

S. L. M. Bakker,

Joost Bot,

Marieke C. Visser,

Irene C. van der Schaaf,

Willem P.Th.M. Mali,

Tom van Seeters,

J.M. Niesten,

Geert Jan Biessels,

Merel J.A. Luitse,

Y. van der Graaf

Publication year - 2016

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.116.013306

Subject(s) - medicine , odds ratio , interquartile range , thrombus , modified rankin scale , fibrinolytic agent , confidence interval , stroke (engine) , thrombolysis , surgery , tissue plasminogen activator , ischemia , ischemic stroke , mechanical engineering , myocardial infarction , engineering

Preclinical studies showed that thrombus permeability improves recombinant tissue-type plasminogen activator (r-tPA) efficacy. We hypothesize that thrombus permeability estimated from radiological imaging is associated with improved recanalization after treatment with intravenously administered r-tPA (r-tPA) and with better functional outcome.

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