Regulation of Caveolin-1 Expression Determines Early Brain Edema After Experimental Focal Cerebral Ischemia | Zendy

KangHo Choi | Zendy; Hyung-Seok Kim | Zendy; ManSeok Park | Zendy; JoonTae Kim | Zendy; Jahae Kim | Zendy; Kyung-Ah Cho | Zendy; Min Cheol Lee | Zendy; Hong-Joon Lee | Zendy; KiHyun Cho | Zendy

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Regulation of Caveolin-1 Expression Determines Early Brain Edema After Experimental Focal Cerebral Ischemia

Author(s) -

KangHo Choi,

Hyung-Seok Kim,

ManSeok Park,

JoonTae Kim,

Jahae Kim,

Kyung-Ah Cho,

Min Cheol Lee,

Hong-Joon Lee,

KiHyun Cho

Publication year - 2016

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.116.013205

Subject(s) - medicine , ischemia , caveolin 1 , blood–brain barrier , matrix metalloproteinase , pathology , vascular permeability , edema , cerebral edema , brain ischemia , tight junction , microbiology and biotechnology , biology , central nervous system

Most patients with cerebral infarction die of brain edema because of the breakdown of the blood-brain barrier (BBB) in ischemic tissue. Caveolins (a group of proteins) are key modulators of vascular permeability; however, a direct role of caveolin-1 (Cav-1) in the regulation of BBB permeability during ischemic injury has yet to be identified.

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