70-kDa Heat Shock Protein Downregulates Dynamin in Experimental Stroke | Zendy

Jong Youl Kim | Zendy; Nuri Kim | Zendy; Zhen Zheng | Zendy; Jong Eun Lee | Zendy; Midori A. Yenari | Zendy

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70-kDa Heat Shock Protein Downregulates Dynamin in Experimental Stroke

Author(s) -

Jong Youl Kim,

Nuri Kim,

Zhen Zheng,

Jong Eun Lee,

Midori A. Yenari

Publication year - 2016

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.116.012763

Subject(s) - dynamin , hsp70 , neuroprotection , knockout mouse , heat shock protein , genetically modified mouse , medicine , apoptosis , dnm1l , pharmacology , transgene , microbiology and biotechnology , receptor , biology , biochemistry , endocytosis , mitochondrial fission , gene

The 70-kDa heat shock protein (Hsp70) protects brain cells in models of cerebral ischemia. Proteomic screening of mice subjected to middle cerebral artery occlusion identified dynamin as a major downregulated protein in Hsp70-overexpressing mice (Hsp70 transgenic mice). Dynamin-1 is expressed in neurons and participates in neurotransmission, but also transports the death receptor Fas to the cell surface, where it can be bound by its ligand and lead to apoptosis.

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