Efficacy of Alteplase in a Mouse Model of Acute Ischemic Stroke | Zendy

Cyrille Orset | Zendy; Benoît Haelewyn | Zendy; Stuart M. Allan | Zendy; Saema Ansar | Zendy; F. A. de M. Campos | Zendy; TaeHee Cho | Zendy; Anne Durand | Zendy; Mohamad El Amki | Zendy; Marc Fatar | Zendy; Isaac GarcíaYébenes | Zendy; Maxime Gauberti | Zendy; Saskia Grudzenski | Zendy; Ignacio Lizasoaín | Zendy; Eng H. Lo | Zendy; Richard Macrez | Zendy; Isabelle Margaill | Zendy; Samaneh Maysami | Zendy; Stephen Meairs | Zendy; Norbert Nighoghossian | Zendy; Josune Orbe | Zendy; José A. Páramo | Zendy; Jean-Jacques Parienti | Zendy; Nancy J. Rothwell | Zendy; Marina Rubio | Zendy; Christian Waeber | Zendy; Alan R. Young | Zendy; Emmanuel Touzé | Zendy; Denis Vivien | Zendy

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Efficacy of Alteplase in a Mouse Model of Acute Ischemic Stroke

Author(s) -

Cyrille Orset,

Benoît Haelewyn,

Stuart M. Allan,

Saema Ansar,

F. A. de M. Campos,

TaeHee Cho,

Anne Durand,

Mohamad El Amki,

Marc Fatar,

Isaac GarcíaYébenes,

Maxime Gauberti,

Saskia Grudzenski,

Ignacio Lizasoaín,

Eng H. Lo,

Richard Macrez,

Isabelle Margaill,

Samaneh Maysami,

Stephen Meairs,

Norbert Nighoghossian,

Josune Orbe,

José A. Páramo,

Jean-Jacques Parienti,

Nancy J. Rothwell,

Marina Rubio,

Christian Waeber,

Alan R. Young,

Emmanuel Touzé,

Denis Vivien

Publication year - 2016

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.116.012238

Subject(s) - medicine , ischemic stroke , stroke (engine) , acute stroke , thrombolysis , fibrinolytic agent , cardiology , ischemia , anesthesia , tissue plasminogen activator , myocardial infarction , mechanical engineering , engineering

The debate over the fact that experimental drugs proposed for the treatment of stroke fail in the translation to the clinical situation has attracted considerable attention in the literature. In this context, we present a retrospective pooled analysis of a large data set from preclinical studies, to examine the effects of early versus late administration of intravenous recombinant tissue-type plasminogen activator.

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