Does Diffusion Lesion Volume Above 70 mL Preclude Favorable Outcome Despite Post-Thrombolysis Recanalization? | Zendy

Marie Tisserand | Zendy; Guillaume Turc | Zendy; Sylvain Charron | Zendy; Laurence Legrand | Zendy; Myriam Edjlali | Zendy; Pierre Seners | Zendy; Pauline Roca | Zendy; Stéphanie Lion | Zendy; Olivier Naggara | Zendy; JeanLouis Mas | Zendy; JeanFrançois Meder | Zendy; JeanClaude Baron | Zendy; Catherine Oppenheim | Zendy

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Does Diffusion Lesion Volume Above 70 mL Preclude Favorable Outcome Despite Post-Thrombolysis Recanalization?

Author(s) -

Marie Tisserand,

Guillaume Turc,

Sylvain Charron,

Laurence Legrand,

Myriam Edjlali,

Pierre Seners,

Pauline Roca,

Stéphanie Lion,

Olivier Naggara,

JeanLouis Mas,

JeanFrançois Meder,

JeanClaude Baron,

Catherine Oppenheim

Publication year - 2016

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.115.012518

Subject(s) - medicine , modified rankin scale , interquartile range , lesion , thrombolysis , magnetic resonance imaging , intracerebral hemorrhage , stroke (engine) , middle cerebral artery , radiology , odds ratio , diffusion mri , nuclear medicine , surgery , ischemia , ischemic stroke , subarachnoid hemorrhage , mechanical engineering , myocardial infarction , engineering

Whether to withhold recanalization treatment when the diffusion-weighted imaging (DWI) lesion exceeds a given volume is unsettled. Our aim was to assess the impact of recanalization on outcome in patients with baseline DWI lesion ≥70 mL (DWI≥70 mL) treated ≤4.5 hours from onset. We hypothesized that recanalization is beneficial in a sizeable fraction of these patients and that this is associated with a larger DWI lesion reversal.

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