Low Circulating Acute Brain-Derived Neurotrophic Factor Levels Are Associated With Poor Long-Term Functional Outcome After Ischemic Stroke | Zendy

Tara M. Stanne | Zendy; N. David Åberg | Zendy; Staffan Nilsson | Zendy; Katarina Jood | Zendy; Christian Blomstrand | Zendy; Ulf Andréasson | Zendy; Kaj Blennow | Zendy; Henrik Zetterberg | Zendy; Jörgen Isgaard | Zendy; Johan Svensson | Zendy; Christina Jern | Zendy

Open Access

Low Circulating Acute Brain-Derived Neurotrophic Factor Levels Are Associated With Poor Long-Term Functional Outcome After Ischemic Stroke

Author(s) -

Tara M. Stanne,

N. David Åberg,

Staffan Nilsson,

Katarina Jood,

Christian Blomstrand,

Ulf Andréasson,

Kaj Blennow,

Henrik Zetterberg,

Jörgen Isgaard,

Johan Svensson,

Christina Jern

Publication year - 2016

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.115.012383

Subject(s) - medicine , modified rankin scale , brain derived neurotrophic factor , odds ratio , stroke (engine) , confidence interval , neurotrophic factors , brain ischemia , risk factor , cardiology , ischemic stroke , ischemia , receptor , mechanical engineering , engineering

Brain-derived neurotrophic factor (BDNF) plays important roles in brain plasticity and repair, and it influences stroke outcomes in animal models. Circulating BDNF concentrations are lowered in patients with traumatic brain injury, and low BDNF predicts poor recovery after this injury. We sought to investigate whether circulating concentrations of BDNF are altered in the acute phase of ischemic stroke and whether they are associated with short- or long-term functional outcome.

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