Open AccessRole of Lipocalin-2 in Thrombin-Induced Brain Injury
Author(s) -
Shanshan Mao,
Guohua Xi,
Richard F. Keep,
Ya Hua
Publication year - 2016
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/strokeaha.115.012153
Subject(s) - thrombin , intracerebral hemorrhage , lipocalin , medicine , neuroinflammation , thrombin receptor , endocrinology , receptor , inflammation , platelet , subarachnoid hemorrhage
Thrombin and lipocalin-2 (LCN2) contribute to intracerebral hemorrhage-induced brain injury. Thrombin-induced brain damage is partially through a thrombin receptor, protease-activated receptor-1. LCN2 is involved in cellular iron transport and neuroinflammation. This study investigated the role of LCN2 in thrombin-induced brain injury.
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