Astrocyte-Derived Pentraxin 3 Supports Blood–Brain Barrier Integrity Under Acute Phase of Stroke | Zendy

Akihiro Shindo | Zendy; Takakuni Maki | Zendy; Emiri T. Mandeville | Zendy; Anna C. Liang | Zendy; Naohiro Egawa | Zendy; Kanako Itoh | Zendy; Naoki Itoh | Zendy; Mia C. Borlongan | Zendy; Julie C. Holder | Zendy; Tsu Tshen Chuang | Zendy; John D. McNeish | Zendy; Hidekazu Tomimoto | Zendy; Josephine Lok | Zendy; Eng H. Lo | Zendy; Ken Arai | Zendy

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Astrocyte-Derived Pentraxin 3 Supports Blood–Brain Barrier Integrity Under Acute Phase of Stroke

Author(s) -

Akihiro Shindo,

Takakuni Maki,

Emiri T. Mandeville,

Anna C. Liang,

Naohiro Egawa,

Kanako Itoh,

Naoki Itoh,

Mia C. Borlongan,

Julie C. Holder,

Tsu Tshen Chuang,

John D. McNeish,

Hidekazu Tomimoto,

Josephine Lok,

Eng H. Lo,

Ken Arai

Publication year - 2016

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.115.012133

Subject(s) - astrocyte , medicine , blood–brain barrier , ptx3 , vascular permeability , vascular endothelial growth factor , endothelial stem cell , brain ischemia , endothelium , inflammation , ischemia , pathology , microbiology and biotechnology , immunology , in vitro , biology , central nervous system , biochemistry , vegf receptors

Pentraxin 3 (PTX3) is released on inflammatory responses in many organs. However, roles of PTX3 in brain are still mostly unknown. Here we asked whether and how PTX3 contributes to blood-brain barrier dysfunction during the acute phase of ischemic stroke.

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