Interleukin-4 Is Essential for Microglia/Macrophage M2 Polarization and Long-Term Recovery After Cerebral Ischemia | Zendy

Xiangrong Liu | Zendy; Jia Liu | Zendy; Shangfeng Zhao | Zendy; Haiyue Zhang | Zendy; Wei Cai | Zendy; Mengfei Cai | Zendy; Xunming Ji | Zendy; Rehana K. Leak | Zendy; Yanqin Gao | Zendy; Jun Chen | Zendy; Xiaoming Hu | Zendy

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Interleukin-4 Is Essential for Microglia/Macrophage M2 Polarization and Long-Term Recovery After Cerebral Ischemia

Author(s) -

Xiangrong Liu,

Jia Liu,

Shangfeng Zhao,

Haiyue Zhang,

Wei Cai,

Mengfei Cai,

Xunming Ji,

Rehana K. Leak,

Yanqin Gao,

Jun Chen,

Xiaoming Hu

Publication year - 2016

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.115.012079

Subject(s) - medicine , microglia , ischemia , morris water navigation task , stroke (engine) , middle cerebral artery , pathology , cytokine , anesthesia , inflammation , hippocampus , mechanical engineering , engineering

Interleukin-4 (IL-4) is a unique cytokine that may contribute to brain repair by regulating microglia/macrophage functions. Thus, we examined the effect of IL-4 on long-term recovery and microglia/macrophage polarization in 2 well-established stroke models.

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