Open AccessHeme–Hemopexin Scavenging Is Active in the Brain and Associates With Outcome After Subarachnoid Hemorrhage
Author(s) -
Patrick Garland,
Andrew Durnford,
Azubuike I. Okemefuna,
J Dunbar,
James A. R. Nicoll,
James Galea,
Delphine Boche,
Diederik Bulters,
Ian Galea
Publication year - 2016
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/strokeaha.115.011956
Subject(s) - medicine , hemopexin , subarachnoid hemorrhage , scavenging , heme , anesthesia , biochemistry , antioxidant , enzyme , chemistry
Long-term outcome after subarachnoid hemorrhage (SAH) is potentially linked to cytotoxic heme. Free heme is bound by hemopexin and rapidly scavenged by CD91. We hypothesized that heme scavenging in the brain would be associated with outcome after hemorrhage.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom