Peroxisome Proliferator–Activated Receptor β/δ Alleviates Early Brain Injury After Subarachnoid Hemorrhage in Rats | Zendy

Zhipeng Teng | Zendy; Li Jiang | Zendy; Qin Hu | Zendy; Yue He | Zendy; ZhenNi Guo | Zendy; Yue Wu | Zendy; Zhijian Huang | Zendy; Fang Cao | Zendy; Chongjie Cheng | Zendy; Xiaochuan Sun | Zendy; Zongduo Guo | Zendy

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Peroxisome Proliferator–Activated Receptor β/δ Alleviates Early Brain Injury After Subarachnoid Hemorrhage in Rats

Author(s) -

Zhipeng Teng,

Li Jiang,

Qin Hu,

Yue He,

ZhenNi Guo,

Yue Wu,

Zhijian Huang,

Fang Cao,

Chongjie Cheng,

Xiaochuan Sun,

Zongduo Guo

Publication year - 2015

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.115.011701

Subject(s) - medicine , extravasation , subarachnoid hemorrhage , downregulation and upregulation , blood–brain barrier , evans blue , peroxisome proliferator activated receptor , traumatic brain injury , apoptosis , agonist , anesthesia , pathology , receptor , endocrinology , central nervous system , biology , biochemistry , psychiatry , gene

Early brain injury is proposed to be the primary cause of the poor outcome after subarachnoid hemorrhage (SAH), which is closely related to the neural apoptosis. To date, the relationship between peroxisome proliferator-activated receptor β/δ (PPARβ/δ) and nuclear factor-κB/matrix metalloproteinase-9 (NF-κB/MMP-9) pathway, both of which are closely related to apoptotic effects, has been poorly studied in SAH. The present study was undertaken to evaluate the effects of PPARβ/δ on early brain injury and NF-κB/MMP-9 pathway after SAH in rats.

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