Matrix Metalloprotease 3 Exacerbates Hemorrhagic Transformation and Worsens Functional Outcomes in Hyperglycemic Stroke | Zendy

Sherif Hafez | Zendy; Mohammed Abdelsaid | Zendy; Sally Elshafey | Zendy; Maribeth H. Johnson | Zendy; Susan C. Fagan | Zendy; Adviye Ergul | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Matrix Metalloprotease 3 Exacerbates Hemorrhagic Transformation and Worsens Functional Outcomes in Hyperglycemic Stroke

Author(s) -

Sherif Hafez,

Mohammed Abdelsaid,

Sally Elshafey,

Maribeth H. Johnson,

Susan C. Fagan,

Adviye Ergul

Publication year - 2016

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.115.011258

Subject(s) - mmp3 , medicine , neurovascular bundle , stroke (engine) , tissue plasminogen activator , intracerebral hemorrhage , anesthesia , surgery , subarachnoid hemorrhage , mechanical engineering , biochemistry , gene expression , chemistry , engineering , gene

Acute hyperglycemia worsens the clinical outcomes and exacerbates cerebral hemorrhage after stroke. The mediators of hemorrhagic transformation (HT) in hyperglycemic stroke are not fully understood. Matrix metalloproteinase 3 (MMP3) plays a critical role in the tissue-type plasminogen activator-induced HT. However, the role of MMP3 in exacerbating the HT and worsening the functional outcomes in hyperglycemic stroke remains unknown.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research