Shear-Activated Nanoparticle Aggregates Combined With Temporary Endovascular Bypass to Treat Large Vessel Occlusion | Zendy

Miklós Marosföi | Zendy; Netanel Korin | Zendy; Matthew J. Gounis | Zendy; Oktay Uzun | Zendy; Srinivasan Vedantham | Zendy; Erin Langan | Zendy; AnneLaure Papa | Zendy; Olivia W. Brooks | Zendy; Chris Johnson | Zendy; Ajit S Puri | Zendy; Deen Bhatta | Zendy; Mathumai Kanapathipillai | Zendy; Ben R. Bronstein | Zendy; Ju-Yu Chueh | Zendy; Donald E. Ingber | Zendy; Ajay K. Wakhloo | Zendy

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Shear-Activated Nanoparticle Aggregates Combined With Temporary Endovascular Bypass to Treat Large Vessel Occlusion

Author(s) -

Miklós Marosföi,

Netanel Korin,

Matthew J. Gounis,

Oktay Uzun,

Srinivasan Vedantham,

Erin Langan,

AnneLaure Papa,

Olivia W. Brooks,

Chris Johnson,

Ajit S Puri,

Deen Bhatta,

Mathumai Kanapathipillai,

Ben R. Bronstein,

Ju-Yu Chueh,

Donald E. Ingber,

Ajay K. Wakhloo

Publication year - 2015

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.115.011063

Subject(s) - medicine , odds ratio , confidence interval , occlusion , cardiology , urology , surgery , anesthesia

The goal of this study is to combine temporary endovascular bypass (TEB) with a novel shear-activated nanotherapeutic (SA-NT) that releases recombinant tissue-type plasminogen activator (r-tPA) when exposed to high levels of hemodynamic stress and to determine if this approach can be used to concentrate r-tPA at occlusion sites based on high shear stresses created by stent placement.

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