Vascular Cell Senescence Contributes to Blood–Brain Barrier Breakdown | Zendy

Yu Yamazaki | Zendy; Darren J. Baker | Zendy; Masaya Tachibana | Zendy; ChiaChen Liu | Zendy; Jan M. van Deursen | Zendy; Thomas Brott | Zendy; Guojun Bu | Zendy; Takahisa Kanekiyo | Zendy

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Vascular Cell Senescence Contributes to Blood–Brain Barrier Breakdown

Author(s) -

Yu Yamazaki,

Darren J. Baker,

Masaya Tachibana,

ChiaChen Liu,

Jan M. van Deursen,

Thomas Brott,

Guojun Bu,

Takahisa Kanekiyo

Publication year - 2016

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.115.010835

Subject(s) - tight junction , blood–brain barrier , microbiology and biotechnology , senescence , adherens junction , evans blue , endothelium , endothelial stem cell , occludin , vascular permeability , in vitro , barrier function , medicine , biology , cell , pathology , central nervous system , neuroscience , endocrinology , cadherin , biochemistry , genetics

Age-related changes in the cerebrovasculature, including blood-brain barrier (BBB) disruption, are emerging as potential risks for diverse neurological conditions. Because the accumulation of senescent cells in tissues is increasingly recognized as a critical step leading to age-related organ dysfunction, we evaluated whether senescent vascular cells are associated with compromised BBB integrity.

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