n -3 Polyunsaturated Fatty Acids Reduce Neonatal Hypoxic/Ischemic Brain Injury by Promoting Phosphatidylserine Formation and Akt Signaling | Zendy

Wenting Zhang | Zendy; Jia Liu | Zendy; Xiaoming Hu | Zendy; Peiying Li | Zendy; Rehana K. Leak | Zendy; Yanqin Gao | Zendy; Jun Chen | Zendy

Open Access

n -3 Polyunsaturated Fatty Acids Reduce Neonatal Hypoxic/Ischemic Brain Injury by Promoting Phosphatidylserine Formation and Akt Signaling

Author(s) -

Wenting Zhang,

Jia Liu,

Xiaoming Hu,

Peiying Li,

Rehana K. Leak,

Yanqin Gao,

Jun Chen

Publication year - 2015

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.115.010815

Subject(s) - docosahexaenoic acid , eicosapentaenoic acid , phosphatidylserine , protein kinase b , polyunsaturated fatty acid , medicine , neuroprotection , pi3k/akt/mtor pathway , endocrinology , biochemistry , biology , apoptosis , fatty acid , phospholipid , membrane

Omega-3 polyunsaturated fatty acids (n-3 PUFAs) attenuate neonatal hypoxic/ischemic (H/I) brain damage, but the underlying mechanisms are not fully understood. This study tested the hypothesis that n-3 PUFAs enhance Akt-dependent prosurvival signaling by promoting the biosynthesis of phosphatidylserine in neuronal cell membranes.

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