Alteplase Reduces Downstream Microvascular Thrombosis and Improves the Benefit of Large Artery Recanalization in Stroke | Zendy

JeanPhilippe Désilles | Zendy; Stéphane Loyau | Zendy; Varouna Syvannarath | Zendy; Jaime Gonzalez-Valcarcel | Zendy; Marie Cantier | Zendy; Liliane Louedec | Zendy; Bertrand Lapergue | Zendy; Pierre Amarenco | Zendy; Nadine Ajzenberg | Zendy; Martine JandrotPerrus | Zendy; JeanBaptiste Michel | Zendy; Benoît HoTinNoé | Zendy; Mikaël Mazighi | Zendy

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Alteplase Reduces Downstream Microvascular Thrombosis and Improves the Benefit of Large Artery Recanalization in Stroke

Author(s) -

JeanPhilippe Désilles,

Stéphane Loyau,

Varouna Syvannarath,

Jaime Gonzalez-Valcarcel,

Marie Cantier,

Liliane Louedec,

Bertrand Lapergue,

Pierre Amarenco,

Nadine Ajzenberg,

Martine JandrotPerrus,

JeanBaptiste Michel,

Benoît HoTinNoé,

Mikaël Mazighi

Publication year - 2015

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.115.010721

Subject(s) - medicine , fibrinogen , stroke (engine) , anesthesia , thrombosis , ischemia , platelet , perfusion , fibrin , thrombus , cardiology , immunology , mechanical engineering , engineering

Downstream microvascular thrombosis (DMT) is known to be a contributing factor to incomplete reperfusion in acute ischemic stroke. The aim of this study was to determine the timing of DMT with intravital imaging and to test the hypothesis that intravenous alteplase infusion could reduce DMT in a transient middle cerebral artery occlusion (MCAO) rat stroke model.

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