Role of Neutrophils in Exacerbation of Brain Injury After Focal Cerebral Ischemia in Hyperlipidemic Mice | Zendy

Josephine Herz | Zendy; Pascal Sabellek | Zendy; Thomas E. Lane | Zendy; Matthias Gunzer | Zendy; Dirk M. Hermann | Zendy; Thorsten R. Doeppner | Zendy

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Role of Neutrophils in Exacerbation of Brain Injury After Focal Cerebral Ischemia in Hyperlipidemic Mice

Author(s) -

Josephine Herz,

Pascal Sabellek,

Thomas E. Lane,

Matthias Gunzer,

Dirk M. Hermann,

Thorsten R. Doeppner

Publication year - 2015

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.115.010620

Subject(s) - medicine , ischemia , exacerbation , stroke (engine) , brain ischemia , pathology , cardiology , anesthesia , mechanical engineering , engineering

Inflammation-related comorbidities contribute to stroke-induced immune responses and brain damage. We previously showed that hyperlipidemia exacerbates ischemic brain injury, which is associated with elevated peripheral and cerebral granulocyte numbers. Herein, we evaluate the contribution of neutrophils to the exacerbation of ischemic brain injury.

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