Fluoxetine Maintains a State of Heightened Responsiveness to Motor Training Early After Stroke in a Mouse Model | Zendy

Kwan Ng | Zendy; Ellen Gibson | Zendy; Robert Hubbard | Zendy; Juemin Yang | Zendy; Brian Caffo | Zendy; Richard O’Brien | Zendy; John W. Krakauer | Zendy; Steven R. Zeiler | Zendy

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Fluoxetine Maintains a State of Heightened Responsiveness to Motor Training Early After Stroke in a Mouse Model

Author(s) -

Kwan Ng,

Ellen Gibson,

Robert Hubbard,

Juemin Yang,

Brian Caffo,

Richard O’Brien,

John W. Krakauer,

Steven R. Zeiler

Publication year - 2015

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.115.010471

Subject(s) - fluoxetine , forelimb , stroke (engine) , medicine , neuroplasticity , physical medicine and rehabilitation , motor cortex , neuroscience , stroke recovery , motor learning , anesthesia , psychology , physical therapy , rehabilitation , receptor , anatomy , stimulation , serotonin , mechanical engineering , engineering

Data from both humans and animal models suggest that most recovery from motor impairment after stroke occurs in a sensitive period that lasts only weeks and is mediated, in part, by an increased responsiveness to training. Here, we used a mouse model of focal cortical stroke to test 2 hypotheses. First, we investigated whether responsiveness to training decreases over time after stroke. Second, we tested whether fluoxetine, which can influence synaptic plasticity and stroke recovery, can prolong the period over which large training-related gains can be elicited after stroke.

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