Obesity, Insulin Resistance, and Incident Small Vessel Disease on Magnetic Resonance Imaging | Zendy

Jennifer L. Dearborn | Zendy; Andrea L.C. Schneider | Zendy; A. Richey Sharrett | Zendy; Thomas H. Mosley | Zendy; Daniel C. Bezerra | Zendy; David S. Knopman | Zendy; Elizabeth Selvin | Zendy; Clifford R. Jack | Zendy; Laura H. Coker | Zendy; Álvaro Alonso | Zendy; Lynne E. Wagenknecht | Zendy; B. Gwen Windham | Zendy; Rebecca F. Gottesman | Zendy

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Obesity, Insulin Resistance, and Incident Small Vessel Disease on Magnetic Resonance Imaging

Author(s) -

Jennifer L. Dearborn,

Andrea L.C. Schneider,

A. Richey Sharrett,

Thomas H. Mosley,

Daniel C. Bezerra,

David S. Knopman,

Elizabeth Selvin,

Clifford R. Jack,

Laura H. Coker,

Álvaro Alonso,

Lynne E. Wagenknecht,

B. Gwen Windham,

Rebecca F. Gottesman

Publication year - 2015

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.115.010060

Subject(s) - medicine , insulin resistance , odds ratio , magnetic resonance imaging , body mass index , metabolic syndrome , hyperintensity , obesity , confidence interval , risk factor , cardiology , radiology

The term metabolic syndrome describes the clustering of risk factors found in many individuals with obesity. Because of their pathophysiology, we hypothesized that 2 features of metabolic syndrome, central obesity and insulin resistance (IR), would be associated with cerebrovascular changes on magnetic resonance imaging, and specifically with incident lacunar disease and not white matter hyperintensity (WMH) progression.

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