Activation of Dopamine D2 Receptor Suppresses Neuroinflammation Through αB-Crystalline by Inhibition of NF-κB Nuclear Translocation in Experimental ICH Mice Model | Zendy

Yang Zhang | Zendy; Yujie Chen | Zendy; Jiang Wu | Zendy; Anatol Manaenko | Zendy; Peng Yang | Zendy; Jiping Tang | Zendy; Weiling Fu | Zendy; John H. Zhang | Zendy

Open Access

Activation of Dopamine D2 Receptor Suppresses Neuroinflammation Through αB-Crystalline by Inhibition of NF-κB Nuclear Translocation in Experimental ICH Mice Model

Author(s) -

Yang Zhang,

Yujie Chen,

Jiang Wu,

Anatol Manaenko,

Peng Yang,

Jiping Tang,

Weiling Fu,

John H. Zhang

Publication year - 2015

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.115.009792

Subject(s) - medicine , neuroinflammation , pharmacology , quinpirole , dopamine receptor d2 , inflammation , microglia , neuroprotection , dopamine , endocrinology

Inflammatory injury plays a critical role in intracerebral hemorrhage (ICH)-induced secondary brain injury. Recently, dopamine D2 receptor (DRD2) is identified as an important component controlling innate immunity and inflammatory response in central nervous system, and αB-crystallin (CRYAB) is a potent negative regulator on inflammatory pathways. Here, we sought to investigate the role of DRD2 on neuroinflammation after experimental ICH and the potential mechanism mediated by CRYAB.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research