Reduced Nicotinamide Adenine Dinucleotide Phosphate, a Pentose Phosphate Pathway Product, Might Be a Novel Drug Candidate for Ischemic Stroke | Zendy

Mei Li | Zendy; Zhipeng Zhou | Zendy; Meiling Sun | Zendy; Lijuan Cao | Zendy; Jieyu Chen | Zendy; Yuanyuan Qin | Zendy; JinHua Gu | Zendy; Feng Han | Zendy; Rui Sheng | Zendy; Junchao Wu | Zendy; YuQiang Ding | Zendy; ZhengHong Qin | Zendy

Open Access

Reduced Nicotinamide Adenine Dinucleotide Phosphate, a Pentose Phosphate Pathway Product, Might Be a Novel Drug Candidate for Ischemic Stroke

Author(s) -

Mei Li,

Zhipeng Zhou,

Meiling Sun,

Lijuan Cao,

Jieyu Chen,

Yuanyuan Qin,

JinHua Gu,

Feng Han,

Rui Sheng,

Junchao Wu,

YuQiang Ding,

ZhengHong Qin

Publication year - 2015

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.115.009687

Subject(s) - nicotinamide adenine dinucleotide phosphate , medicine , pentose phosphate pathway , neuroprotection , stroke (engine) , ischemia , pharmacology , nicotinamide adenine dinucleotide , anesthesia , glycolysis , biochemistry , nad+ kinase , enzyme , biology , metabolism , mechanical engineering , oxidase test , engineering

Our previous study has defined a role of TP53-induced glycolysis and apoptosis regulator in neuroprotection against ischemic injury through increasing the flow of pentose phosphate pathway. We hypothesized that the pentose phosphate pathway product nicotinamide adenine dinucleotide phosphate (NADPH) could be a novel drug for treatment of ischemic stroke.

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