Do Patient Characteristics Explain the Differences in Outcome Between Medically Treated Patients in SAMMPRIS and WASID? | Zendy

Seemant Chaturvedi | Zendy; Tanya N. Turan | Zendy; Michael Lynn | Zendy; Colin P. Derdeyn | Zendy; David Fiorella | Zendy; L. Scott Janis | Zendy; Marc I. Chimowitz | Zendy

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Do Patient Characteristics Explain the Differences in Outcome Between Medically Treated Patients in SAMMPRIS and WASID?

Author(s) -

Seemant Chaturvedi,

Tanya N. Turan,

Michael Lynn,

Colin P. Derdeyn,

David Fiorella,

L. Scott Janis,

Marc I. Chimowitz

Publication year - 2015

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.115.009656

Subject(s) - medicine , hazard ratio , confidence interval , aspirin , clinical endpoint , stroke (engine) , proportional hazards model , confounding , log rank test , randomized controlled trial , mechanical engineering , engineering

The Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis (SAMMPRIS) medical group had a much lower primary end point rate than predicted from the preceding Warfarin Aspirin Symptomatic Intracranial Disease (WASID) trial. This result has been attributed to the aggressive medical therapy used in SAMMPRIS, but an alternative hypothesis is that SAMMPRIS patients were at lower risk. We undertook analyses to evaluate these competing hypotheses.

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