Effect of Hyperacute Administration (Within 6 Hours) of Transdermal Glyceryl Trinitrate, a Nitric Oxide Donor, on Outcome After Stroke | Zendy

Lisa J Woodhouse | Zendy; Polly Scutt | Zendy; Kailash Krishnan | Zendy; Eivind Berge | Zendy; John Gommans | Zendy; George Ntaios | Zendy; Joanna M. Wardlaw | Zendy; Nikola Sprigg | Zendy; Philip M. Bath | Zendy

Open Access

Effect of Hyperacute Administration (Within 6 Hours) of Transdermal Glyceryl Trinitrate, a Nitric Oxide Donor, on Outcome After Stroke

Author(s) -

Lisa J Woodhouse,

Polly Scutt,

Kailash Krishnan,

Eivind Berge,

John Gommans,

George Ntaios,

Joanna M. Wardlaw,

Nikola Sprigg,

Philip M. Bath

Publication year - 2015

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.115.009647

Subject(s) - medicine , stroke (engine) , modified rankin scale , confidence interval , odds ratio , anesthesia , randomized controlled trial , hazard ratio , adverse effect , ischemia , ischemic stroke , mechanical engineering , engineering

Nitric oxide donors are candidate treatments for acute stroke, potentially through hemodynamic, reperfusion, and neuroprotectant effects, especially if given early. Although the large Efficacy of Nitric Oxide in Stroke (ENOS) trial of transdermal glyceryl trinitrate (GTN) was neutral, a prespecified subgroup suggested that GTN improved functional outcome if administered early after stroke onset.

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