Role of Acute Lesion Topography in Initial Ischemic Stroke Severity and Long-Term Functional Outcomes | Zendy

Ona Wu | Zendy; Lisa Cloonan | Zendy; Steven J. T. Mocking | Zendy; Mark J.R.J. Bouts | Zendy; William A. Copen | Zendy; Pedro Cougo | Zendy; Kaitlin Fitzpatrick | Zendy; Allison Kanakis | Zendy; Pamela W. Schaefer | Zendy; Jonathan Rosand | Zendy; Karen L. Furie | Zendy; Natalia S. Rost | Zendy

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Role of Acute Lesion Topography in Initial Ischemic Stroke Severity and Long-Term Functional Outcomes

Author(s) -

Ona Wu,

Lisa Cloonan,

Steven J. T. Mocking,

Mark J.R.J. Bouts,

William A. Copen,

Pedro Cougo,

Kaitlin Fitzpatrick,

Allison Kanakis,

Pamela W. Schaefer,

Jonathan Rosand,

Karen L. Furie,

Natalia S. Rost

Publication year - 2015

Publication title -

stroke

Language(s) - English

Resource type - Journals

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.115.009643

Subject(s) - medicine , modified rankin scale , stroke (engine) , magnetic resonance imaging , superior longitudinal fasciculus , diffusion mri , lesion , cardiology , inferior longitudinal fasciculus , radiology , surgery , fractional anisotropy , ischemia , ischemic stroke , engineering , mechanical engineering

Acute infarct volume, often proposed as a biomarker for evaluating novel interventions for acute ischemic stroke, correlates only moderately with traditional clinical end points, such as the modified Rankin Scale. We hypothesized that the topography of acute stroke lesions on diffusion-weighted magnetic resonance imaging may provide further information with regard to presenting stroke severity and long-term functional outcomes.

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