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Long-Term Blood–Brain Barrier Permeability Changes in Binswanger Disease
Author(s) -
Branko N. Huisa,
Arvind Caprihan,
Jeffrey Thompson,
Jillian Prestopnik,
Clifford Qualls,
Gary A. Rosenberg
Publication year - 2015
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/strokeaha.115.009589
Subject(s) - medicine , hyperintensity , magnetic resonance imaging , white matter , analysis of variance , blood–brain barrier , cardiology , nuclear medicine , pathology , radiology , central nervous system
The blood-brain barrier (BBB) is disrupted in small vessel disease patients with lacunes and white matter hyperintensities (WMHs). The relationship of WMHs and regional BBB permeability changes has not been studied. We hypothesized that BBB disruption occurs in normal appearing WM and regions near the WMHs. To test the hypothesis, we repeated BBB permeability measurements in patients with extensive WMHs related to Binswanger disease.

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