Prophylactic Edaravone Prevents Transient Hypoxic-Ischemic Brain Injury | Zendy

Yu Sun | Zendy; Yikun Li | Zendy; Bushra Wali | Zendy; Yuancheng Li | Zendy; Jolly Lee | Zendy; Andrew Heinmiller | Zendy; Kōji Abe | Zendy; Donald G. Stein | Zendy; Hui Mao | Zendy; Iqbal Sayeed | Zendy; Chia-Yi Kuan | Zendy

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Prophylactic Edaravone Prevents Transient Hypoxic-Ischemic Brain Injury

Author(s) -

Yu Sun,

Yikun Li,

Bushra Wali,

Yuancheng Li,

Jolly Lee,

Andrew Heinmiller,

Kōji Abe,

Donald G. Stein,

Hui Mao,

Iqbal Sayeed,

Chia-Yi Kuan

Publication year - 2015

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.115.009162

Subject(s) - edaravone , medicine , free radical scavenger , anesthesia , ischemia , cerebral blood flow , oxidative stress , cardiology

Hypoperfusion-induced thrombosis is an important mechanism for postsurgery stroke and cognitive decline, but there are no perioperative neuroprotectants to date. This study investigated whether prophylactic application of Edaravone, a free radical scavenger already used in treating ischemic stroke in Japan, can prevent infarct and cognitive deficits in a murine model of transient cerebral hypoxia-ischemia.

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