Synergistic Effects of Transplanted Endothelial Progenitor Cells and RWJ 67657 in Diabetic Ischemic Stroke Models | Zendy

Yingying Bai | Zendy; Lishan Wang | Zendy; Di Chang | Zendy; Zhen Zhao | Zendy; ChunQiang Lu | Zendy; Guozheng Wang | Zendy; Shenghong Ju | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Synergistic Effects of Transplanted Endothelial Progenitor Cells and RWJ 67657 in Diabetic Ischemic Stroke Models

Author(s) -

Yingying Bai,

Lishan Wang,

Di Chang,

Zhen Zhao,

ChunQiang Lu,

Guozheng Wang,

Shenghong Ju

Publication year - 2015

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.114.008495

Subject(s) - medicine , angiogenesis , transplantation , endothelial progenitor cell , progenitor cell , neurogenesis , vascular endothelial growth factor , stroke (engine) , neurotrophic factors , pharmacology , stem cell , neuroscience , biology , microbiology and biotechnology , receptor , mechanical engineering , engineering , vegf receptors

An immature vascular phenotype in diabetes mellitus may cause more severe vascular damage and poorer functional outcomes after stroke, and it would be feasible to repair damaged functional vessels using endothelial progenitor cell (EPC) transplantation. However, high glucose induces p38 mitogen-activated protein kinase activation, which can accelerate the senescence and apoptosis of EPCs. The aim of this study was to investigate the combined effects of EPC transplantation and p38 mitogen-activated protein kinase inhibitor administration on diabetic stroke outcomes.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research