Receptor for Advanced Glycation End-Product Antagonist Reduces Blood–Brain Barrier Damage After Intracerebral Hemorrhage | Zendy

Fan Yang | Zendy; Zhe Wang | Zendy; John H. Zhang | Zendy; Jiping Tang | Zendy; Xin Liu | Zendy; Liang Tan | Zendy; Qingyuan Huang | Zendy; Hua Feng | Zendy

Open Access

Receptor for Advanced Glycation End-Product Antagonist Reduces Blood–Brain Barrier Damage After Intracerebral Hemorrhage

Author(s) -

Fan Yang,

Zhe Wang,

John H. Zhang,

Jiping Tang,

Xin Liu,

Liang Tan,

Qingyuan Huang,

Hua Feng

Publication year - 2015

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.114.008336

Subject(s) - medicine , rage (emotion) , hmgb1 , occludin , proinflammatory cytokine , pharmacology , blood–brain barrier , evans blue , neuroprotection , intracerebral hemorrhage , endocrinology , nitric oxide synthase , receptor , inflammation , nitric oxide , chemistry , tight junction , central nervous system , biology , biochemistry , neuroscience , subarachnoid hemorrhage

To determine whether the receptor for advanced glycation end-products (RAGE) plays a role in early brain injury from intracerebral hemorrhage (ICH), RAGE expression and activation after injury were examined in a rat model of ICH with or without administration of a RAGE-specific antagonist (FPS-ZM1).

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