Genetic Overlap Between Diagnostic Subtypes of Ischemic Stroke | Zendy

Elizabeth Holliday | Zendy; Matthew Traylor | Zendy; Rainer Malik | Zendy; Steve Bevan | Zendy; Guido J. Falcone | Zendy; Jemma C. Hopewell | Zendy; Yu-Ching Cheng | Zendy; Ioana Cotlarciuc | Zendy; Joshua C. Bis | Zendy; Eric Boerwinkle | Zendy; Giorgio B. Boncoraglio | Zendy; Robert Clarke | Zendy; John W. Cole | Zendy; Myriam Fornage | Zendy; Karen L. Furie | Zendy; M. Arfan Ikram | Zendy; Jim Jannes | Zendy; Steven J. Kittner | Zendy; Lisa F. Lincz | Zendy; Jane Maguire | Zendy; James F. Meschia | Zendy; Thomas H. Mosley | Zendy; Mike A. Nalls | Zendy; Christopher Oldmeadow | Zendy; Eugenio Parati | Zendy; Bruce M. Psaty | Zendy; Peter M. Rothwell | Zendy; Sudha Seshadri | Zendy; Rodney J. Scott | Zendy; Pankaj Sharma | Zendy; Cathie Sudlow | Zendy; Kerri L. Wiggins | Zendy; Bradford B. Worrall | Zendy; Jonathan Rosand | Zendy; Braxton D. Mitchell | Zendy; Martin Dichgans | Zendy; Hugh S. Markus | Zendy; Christopher Levi | Zendy; John Attia | Zendy; Naomi R. Wray | Zendy

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Genetic Overlap Between Diagnostic Subtypes of Ischemic Stroke

Author(s) -

Elizabeth Holliday,

Matthew Traylor,

Rainer Malik,

Steve Bevan,

Guido J. Falcone,

Jemma C. Hopewell,

Yu-Ching Cheng,

Ioana Cotlarciuc,

Joshua C. Bis,

Eric Boerwinkle,

Giorgio B. Boncoraglio,

Robert Clarke,

John W. Cole,

Myriam Fornage,

Karen L. Furie,

M. Arfan Ikram,

Jim Jannes,

Steven J. Kittner,

Lisa F. Lincz,

Jane Maguire,

James F. Meschia,

Thomas H. Mosley,

Mike A. Nalls,

Christopher Oldmeadow,

Eugenio Parati,

Bruce M. Psaty,

Peter M. Rothwell,

Sudha Seshadri,

Rodney J. Scott,

Pankaj Sharma,

Cathie Sudlow,

Kerri L. Wiggins,

Bradford B. Worrall,

Jonathan Rosand,

Braxton D. Mitchell,

Martin Dichgans,

Hugh S. Markus,

Christopher Levi,

John Attia,

Naomi R. Wray

Publication year - 2015

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.114.007930

Subject(s) - medicine , stroke (engine) , heritability , confidence interval , sample size determination , single nucleotide polymorphism , genome wide association study , genetic heterogeneity , bioinformatics , genotype , genetics , phenotype , gene , biology , statistics , mechanical engineering , mathematics , engineering

Despite moderate heritability, the phenotypic heterogeneity of ischemic stroke has hampered gene discovery, motivating analyses of diagnostic subtypes with reduced sample sizes. We assessed evidence for a shared genetic basis among the 3 major subtypes: large artery atherosclerosis (LAA), cardioembolism, and small vessel disease (SVD), to inform potential cross-subtype analyses.

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