Genes From a Translational Analysis Support a Multifactorial Nature of White Matter Hyperintensities | Zendy

Lorna M. Lopez | Zendy; W. David Hill | Zendy; Sarah E. Harris | Zendy; María Valdés Hernández | Zendy; Susana Muñoz Maniega | Zendy; Mark E. Bastin | Zendy; Emma Bailey | Zendy; Colin Smith | Zendy; Martin McBride | Zendy; John McClure | Zendy; Delyth Graham | Zendy; Anna F. Dominiczak | Zendy; Qiong Yang | Zendy; Myriam Fornage | Zendy; M. Arfan Ikram | Zendy; Stéphanie Debette | Zendy; Lenore J. Launer | Zendy; Joshua C. Bis | Zendy; Reinhold Schmidt | Zendy; Sudha Seshadri | Zendy; David J. Porteous | Zendy; John M. Starr | Zendy; Ian J. Deary | Zendy; Joanna M. Wardlaw | Zendy

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Genes From a Translational Analysis Support a Multifactorial Nature of White Matter Hyperintensities

Author(s) -

Lorna M. Lopez,

W. David Hill,

Sarah E. Harris,

María Valdés Hernández,

Susana Muñoz Maniega,

Mark E. Bastin,

Emma Bailey,

Colin Smith,

Martin McBride,

John McClure,

Delyth Graham,

Anna F. Dominiczak,

Qiong Yang,

Myriam Fornage,

M. Arfan Ikram,

Stéphanie Debette,

Lenore J. Launer,

Joshua C. Bis,

Reinhold Schmidt,

Sudha Seshadri,

David J. Porteous,

John M. Starr,

Ian J. Deary,

Joanna M. Wardlaw

Publication year - 2015

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.114.007649

Subject(s) - medicine , stroke (engine) , hyperintensity , dementia , heritability , genome wide association study , disease , cohort , white matter , cardiology , gene , genetics , magnetic resonance imaging , single nucleotide polymorphism , biology , genotype , engineering , radiology , mechanical engineering

White matter hyperintensities (WMH) of presumed vascular origin increase the risk of stroke and dementia. Despite strong WMH heritability, few gene associations have been identified. Relevant experimental models may be informative.

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