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Persistent Cerebrovascular Damage After Stroke in Type Two Diabetic Rats Measured by Magnetic Resonance Imaging
Author(s) -
Guangliang Ding,
Tao Yan,
Jieli Chen,
Michael Chopp,
Lian Li,
Qingjiang Li,
Chengcheng Cui,
Ruizhuo Ning,
Quan Jiang
Publication year - 2014
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/strokeaha.114.007538
Subject(s) - medicine , stroke (engine) , magnetic resonance imaging , diabetes mellitus , middle cerebral artery , lesion , occlusion , blood–brain barrier , type 2 diabetes mellitus , streptozotocin , ischemia , pathology , anesthesia , endocrinology , radiology , central nervous system , mechanical engineering , engineering
Diabetes mellitus is a disease with vascular components. Consequently, the blood-brain barrier disruption after stroke may differ between diabetic and nondiabetic animals. However, few studies have documented the longitudinal blood-brain barrier disruption afte stroke in diabetic animals. In this study, using MRI, we noninvasively evaluated the blood-brain barrier damage after middle cerebral artery occlusion in diabetic and nondiabetic rats.

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