Blood–Brain Barrier KCa3.1 Channels | Zendy

YiJe Chen | Zendy; Breanna Wallace | Zendy; Natalie Yuen | Zendy; David P. Jenkins | Zendy; Heike Wulff | Zendy; Martha E. O’Donnell | Zendy

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Blood–Brain Barrier KCa3.1 Channels

Author(s) -

YiJe Chen,

Breanna Wallace,

Natalie Yuen,

David P. Jenkins,

Heike Wulff,

Martha E. O’Donnell

Publication year - 2014

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.114.007445

Subject(s) - blood–brain barrier , medicine , endothelium , transcellular , western blot , evans blue , ischemia , endothelial stem cell , microbiology and biotechnology , pathology , central nervous system , biology , biochemistry , gene , in vitro

KCa3.1, a calcium-activated potassium channel, regulates ion and fluid secretion in the lung and gastrointestinal tract. It is also expressed on vascular endothelium where it participates in blood pressure regulation. However, the expression and physiological role of KCa3.1 in blood-brain barrier (BBB) endothelium has not been investigated. BBB endothelial cells transport Na(+) and Cl(-) from the blood into the brain transcellularly through the co-operation of multiple cotransporters, exchangers, pumps, and channels. In the early stages of cerebral ischemia, when the BBB is intact, edema formation occurs by processes involving increased BBB transcellular Na(+) transport. This study evaluated whether KCa3.1 is expressed on and participates in BBB ion transport.

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