Deficiency of the Stroke Relevant HDAC9 Gene Attenuates Atherosclerosis in Accord With Allele-Specific Effects at 7p21.1 | Zendy

Sepiede Azghandi | Zendy; Caroline Prell | Zendy; Sander W. van der Laan | Zendy; Manuela Schneider | Zendy; Rainer Malik | Zendy; Kerstin Berer | Zendy; Norbert Gerdes | Zendy; Gerard Pasterkamp | Zendy; Christian Weber | Zendy; Christof Haffner | Zendy; Martin Dichgans | Zendy

Open Access

Deficiency of the Stroke Relevant HDAC9 Gene Attenuates Atherosclerosis in Accord With Allele-Specific Effects at 7p21.1

Author(s) -

Sepiede Azghandi,

Caroline Prell,

Sander W. van der Laan,

Manuela Schneider,

Rainer Malik,

Kerstin Berer,

Norbert Gerdes,

Gerard Pasterkamp,

Christian Weber,

Christof Haffner,

Martin Dichgans

Publication year - 2014

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.114.007213

Subject(s) - medicine , apolipoprotein e , allele , stroke (engine) , pathology , immunology , disease , gene , biology , genetics , mechanical engineering , engineering

Recent genome-wide association studies identified the histone deacetylase 9 (HDAC9) gene region as a major risk locus for large-vessel stroke and coronary artery disease. However, the mechanisms linking variants at this locus to vascular risk are poorly understood. In this study, we investigated the candidacy and directionality of HDAC9 in atherosclerosis and analyzed associations between risk alleles at 7p21.1 and plaque characteristics.

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