Deficiency of Brain ATP-Binding Cassette Transporter A-1 Exacerbates Blood–Brain Barrier and White Matter Damage After Stroke | Zendy

Xu Cui | Zendy; Michael Chopp | Zendy; Alex Zacharek | Zendy; Joanna M. Karasinska | Zendy; Yisheng Cui | Zendy; Ruizhuo Ning | Zendy; Yi Zhang | Zendy; Yun Wang | Zendy; Jieli Chen | Zendy

Open Access

Deficiency of Brain ATP-Binding Cassette Transporter A-1 Exacerbates Blood–Brain Barrier and White Matter Damage After Stroke

Author(s) -

Xu Cui,

Michael Chopp,

Alex Zacharek,

Joanna M. Karasinska,

Yisheng Cui,

Ruizhuo Ning,

Yi Zhang,

Yun Wang,

Jieli Chen

Publication year - 2015

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.114.007145

Subject(s) - abca1 , medicine , blood–brain barrier , neuroprotection , astrocyte , endocrinology , aquaporin 4 , white matter , biology , transporter , central nervous system , biochemistry , magnetic resonance imaging , radiology , gene

The ATP-binding cassette transporter A-1 (ABCA1) gene is a key target of the transcription factors liver X receptors. Liver X receptor activation has anti-inflammatory and neuroprotective effects in animal ischemic stroke models. Here, we tested the hypothesis that brain ABCA1 reduces blood-brain barrier (BBB) and white matter (WM) impairment in the ischemic brain after stroke.

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