Ethanol and Normobaric Oxygen | Zendy

Xiaokun Geng | Zendy; Omar Elmadhoun | Zendy; Changya Peng | Zendy; Xunming Ji | Zendy; Adam Hafeez | Zendy; Zongjian Liu | Zendy; Huishan Du | Zendy; José A. Rafols | Zendy; Yuchuan Ding | Zendy

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Ethanol and Normobaric Oxygen

Author(s) -

Xiaokun Geng,

Omar Elmadhoun,

Changya Peng,

Xunming Ji,

Adam Hafeez,

Zongjian Liu,

Huishan Du,

José A. Rafols,

Yuchuan Ding

Publication year - 2015

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.114.006994

Subject(s) - medicine , oxygen , anesthesia , organic chemistry , chemistry

Ischemic stroke induces metabolic disarray. A central regulatory site, pyruvate dehydrogeanse complex (PDHC) sits at the cross-roads of 2 fundamental metabolic pathways: aerobic and anaerobic. In this study, we combined ethanol (EtOH) and normobaric oxygen (NBO) to develop a novel treatment to modulate PDHC and its regulatory proteins, namely pyruvate dehydrogenase phosphatase and pyruvate dehydrogenase kinase, leading to improved metabolism and reduced oxidative damage.

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