Delayed Pituitary Adenylate Cyclase–Activating Polypeptide Delivery After Brain Stroke Improves Functional Recovery by Inducing M2 Microglia/Macrophage Polarization | Zendy

Coralie Brifault | Zendy; Marjorie Gras | Zendy; Donovan Liot | Zendy; Víctor May | Zendy; David Vaudry | Zendy; Olivier Wurtz | Zendy

Open Access

Delayed Pituitary Adenylate Cyclase–Activating Polypeptide Delivery After Brain Stroke Improves Functional Recovery by Inducing M2 Microglia/Macrophage Polarization

Author(s) -

Coralie Brifault,

Marjorie Gras,

Donovan Liot,

Víctor May,

David Vaudry,

Olivier Wurtz

Publication year - 2014

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.114.006864

Subject(s) - neuroprotection , medicine , microglia , pituitary adenylate cyclase activating peptide , ischemia , inflammation , pharmacology , neuroscience , microbiology and biotechnology , immunology , neuropeptide , biology , vasoactive intestinal peptide , receptor

Until now, except thrombolysis, the therapeutical strategies targeting the acute phase of cerebral ischemia have been proven ineffective, and no approach is available to attenuate the delayed cell death mechanisms and the resulting functional deficits in the late phase. Then, we investigated whether a targeted and delayed delivery of pituitary adenylate cyclase-activating polypeptide (PACAP), a peptide known to exert neuroprotective activities, may dampen delayed pathophysiological processes improving functional recovery.

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