Intraluminal Cell Transplantation Prevents Growth and Rupture in a Model of Rupture-Prone Saccular Aneurysms | Zendy

Serge Marbacher | Zendy; Juhana Frösén | Zendy; Johan Marjamaa | Zendy; A. Yu. Anisimov | Zendy; Petri Honkanen | Zendy; Michael von Gunten | Zendy; Usama AboRamadan | Zendy; Juha Hernesniemi | Zendy; Mika Niemelä | Zendy

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Intraluminal Cell Transplantation Prevents Growth and Rupture in a Model of Rupture-Prone Saccular Aneurysms

Author(s) -

Serge Marbacher,

Juhana Frösén,

Johan Marjamaa,

A. Yu. Anisimov,

Petri Honkanen,

Michael von Gunten,

Usama AboRamadan,

Juha Hernesniemi,

Mika Niemelä

Publication year - 2014

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.114.006600

Subject(s) - neointima , aneurysm , medicine , thrombus , decellularization , fibrin , thrombosis , transplantation , fusiform aneurysm , radiology , surgery , stent , tissue engineering , biomedical engineering , restenosis , immunology

Aneurysm occlusion by intraluminal thrombus formation is the desired effect of all endovascular treatments. Intraluminal thrombus may, however, recanalize and be absorbed, unless it is infiltrated by cells that turn it into fibrous tissue (neointima). Because ruptured aneurysm walls are characterized by loss of smooth muscle cells, we assessed the impact of mural cell loss on wall remodeling of thrombosed aneurysms and investigated whether neointima formation could be enhanced by direct transplantation of cells into the thrombus.

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