17β-Estradiol Attenuates Hematoma Expansion Through Estrogen Receptor α/Silent Information Regulator 1/Nuclear Factor-kappa B Pathway in Hyperglycemic Intracerebral Hemorrhage Mice | Zendy

Yun Zheng | Zendy; Qin Hu | Zendy; Anatol Manaenko | Zendy; Yang Zhang | Zendy; Yan Peng | Zendy; Liang Xu | Zendy; Junjia Tang | Zendy; Jiping Tang | Zendy; John H. Zhang | Zendy

Open Access

17β-Estradiol Attenuates Hematoma Expansion Through Estrogen Receptor α/Silent Information Regulator 1/Nuclear Factor-kappa B Pathway in Hyperglycemic Intracerebral Hemorrhage Mice

Author(s) -

Yun Zheng,

Qin Hu,

Anatol Manaenko,

Yang Zhang,

Yan Peng,

Liang Xu,

Junjia Tang,

Jiping Tang,

John H. Zhang

Publication year - 2014

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.114.006372

Subject(s) - medicine , intracerebral hemorrhage , regulator , estrogen receptor , stroke (engine) , estrogen , kappa , hematoma , endocrinology , surgery , gene , biochemistry , breast cancer , cancer , mechanical engineering , chemistry , linguistics , philosophy , engineering , subarachnoid hemorrhage

17β-estradiol (E2) has been reported to reduce bleeding and brain injury in experimental intracerebral hemorrhage (ICH) model. However, it is not clear if E2 can prevent early hematoma expansion (HE) induced by hyperglycemia in acute ICH. The aim of this study is to evaluate the effects of E2 on HE and its potential mechanisms in hyperglycemic ICH mice.

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