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17β-estradiol (E2) has been reported to reduce bleeding and brain injury in experimental intracerebral hemorrhage (ICH) model. However, it is not clear if E2 can prevent early hematoma expansion (HE) induced by hyperglycemia in acute ICH. The aim of this study is to evaluate the effects of E2 on HE and its potential mechanisms in hyperglycemic ICH mice.

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17β-Estradiol Attenuates Hematoma Expansion Through Estrogen Receptor α/Silent Information Regulator 1/Nuclear Factor-kappa B Pathway in Hyperglycemic Intracerebral Hemorrhage Mice