Postischemic Reperfusion Causes Smooth Muscle Calcium Sensitization and Vasoconstriction of Parenchymal Arterioles | Zendy

Marilyn J. Cipolla | Zendy; SiuLung Chan | Zendy; Julie Sweet | Zendy; Matthew Tavares | Zendy; Natalia I. Gokina | Zendy; Joseph E. Brayden | Zendy

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Postischemic Reperfusion Causes Smooth Muscle Calcium Sensitization and Vasoconstriction of Parenchymal Arterioles

Author(s) -

Marilyn J. Cipolla,

SiuLung Chan,

Julie Sweet,

Matthew Tavares,

Natalia I. Gokina,

Joseph E. Brayden

Publication year - 2014

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.114.005888

Subject(s) - medicine , vasoconstriction , calcium , endocrinology , perfusion , ischemia , anesthesia , depolarization , arteriole , protein kinase c , anatomy , microcirculation , kinase , biochemistry , biology

Parenchymal arterioles (PAs) are high-resistance vessels in the brain that connect pial vessels to the microcirculation. We previously showed that PAs have increased vasoconstriction after ischemia and reperfusion that could increase perfusion deficit. Here, we investigated underlying mechanisms by which early postischemic reperfusion causes increased vasoconstriction of PAs.

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