Open AccessCan Response-Adaptive Randomization Increase Participation in Acute Stroke Trials?
Author(s) -
Jason Tehranisa,
William J. Meurer
Publication year - 2014
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/strokeaha.114.005418
Subject(s) - medicine , randomization , acute stroke , stroke (engine) , clinical trial , physical therapy , tissue plasminogen activator , engineering , mechanical engineering
A response-adaptive randomization (RAR) trial design actively adjusts the ratio of participants assigned to each trial arm, favoring the better performing treatment by using outcome data from participants already in the trial. Compared with a standard clinical trial, an RAR study design has the potential to improve patient participation in acute stroke trials.
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